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BLOOD PLASMA PROTEIN REGENERATION CONTROLLED BY DIET : SYSTEMATIC STANDARDIZATION OF FOOD PROTEINS FOR POTENCY IN
W T Pommerenke1, H B Slavin, D H Kariher
1Department of Pathology, School of Medicine and Dentistry, The University of Rochester, Rochester, N. Y.
The Journal of Experimental Medicine
|October 30, 2009
Summary
Dogs depleted of plasma proteins can regenerate them using specific food proteins. Beef serum and some grain proteins are highly potent, while kidney protein is least effective, offering insights into diet and hypoproteinemia.
Area of Science:
- Biochemistry
- Animal Nutrition
- Physiology
Background:
- Plasma protein depletion can be induced and maintained in dogs via plasmapheresis.
- Such depleted dogs serve as models for studying dietary factors in plasma protein regeneration.
Purpose of the Study:
- To measure the potency of various dietary proteins for plasma protein regeneration in dogs.
- To establish potency ratios for different food proteins.
Main Methods:
- Dogs underwent plasmapheresis to deplete plasma proteins, achieving a steady state.
- The capacity of various food proteins to regenerate plasma proteins was assessed by calculating potency ratios.
Main Results:
- Potency ratios varied significantly, with beef serum (2.6) and some grain proteins (2.7-4.6) being highly potent, while kidney protein (21.0) was least potent.
- Muscle, egg white, and lactalbumin showed favorable ratios (5.3-6.0), whereas liver, casein, and heart were moderately potent (6.5-8.0).
- Fasting inhibited plasma protein production; iron supplementation unexpectedly increased it.
Conclusions:
- Dietary protein source critically impacts plasma protein regeneration efficiency.
- Findings inform dietary strategies for managing hypoproteinemia and related clinical conditions.
- Protein combinations and health status may influence dietary protein potency.
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