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THE DISTRIBUTION OF SWINE INFLUENZA VIRUS IN SWINE.
1Department of Animal and Plant Pathology of The Rockefeller Institute for Medical Research, Princeton, N. J.
The Journal of Experimental Medicine
|October 30, 2009
Summary
Swine influenza virus primarily infects respiratory tissues like lungs and turbinates in pigs. This pneumotropic virus was not detected in organs such as the spleen, liver, or brain.
Area of Science:
- Veterinary Virology
- Animal Pathology
Background:
- Swine influenza virus (SIV) poses significant threats to swine health and global food security.
- Understanding the tissue tropism of SIV is crucial for disease control and prevention.
Purpose of the Study:
- To determine the distribution and localization of swine influenza virus in various tissues of experimentally infected swine.
Main Methods:
- Post-mortem examination of experimentally infected swine.
- Detection of swine influenza virus in multiple tissue samples, including respiratory tract, lymphoid tissues, and organs.
Main Results:
- Swine influenza virus was consistently detected in turbinates, tracheal exudate, and lungs.
- The virus was absent in spleen, liver, kidneys, mesenteric lymph nodes, colon mucosae, brain, and blood.
- Low viral concentrations were found in bronchial lymph nodes of 2 out of 8 animals.
Conclusions:
- The observed tissue distribution confirms the pneumotropic nature of swine influenza virus.
- These findings highlight the respiratory system as the primary site of SIV replication and persistence in swine.
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