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Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency
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A CHANGE IN RABBIT FIBROMA VIRUS SUGGESTING MUTATION : III. INTERPRETATION OF FINDINGS

C H Andrewes1, R E Shope

  • 1National Institute for Medical Research, Hampstead, London, and the Department of Animal and Plant Pathology of The Rockefeller Institute for Medical Research, Princeton, N. J.

The Journal of Experimental Medicine
|October 30, 2009
PubMed

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Viral Mutations00:36

Viral Mutations

A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material for adaptive...