Related Experiment Video
Updated: Jun 19, 2026

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
Published on: August 30, 2014
THE PROTECTIVE ACTION OF NASALLY INSTILLED IMMUNE SERUM AGAINST INFECTION WITH CERTAIN NEUROTROPIC VIRUSES BY WAY OF
1Laboratories of The Rockefeller Institute for Medical Research.
Abstract:
1. Immune serum instilled intranasally in guinea pigs has protected them from infection with lethal amounts of pseudorabies virus by the nasal route. The same effect was obtained in mice with immune serum against the virus of equine encephalomyelitis (Eastern strain). 2. The protective effect of the immune serum in the nose begins at the time of instillation, is still evident 5 hours later, and usually has disappeared by the end of 24 hours. 3. Attempts to prolong the local effectiveness of immune serum by means of several devices were unsuccessful. 4. The action of the immune serum appears to be a local one in the nose, in view of the fact that the administration of even larger amounts of it intramuscularly failed to protect guinea pigs against infection with pseudorabies by the nasal route.
More Related Videos
07:04Immunostimulatory Agent Evaluation: Lymphoid Tissue Extraction and Injection Route-Dependent Dendritic Cell Activation
Published on: September 16, 2018
07:33Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo
Published on: September 28, 2022
Related Concept Videos
Respiratory Syncytial Virus Disease
Inhibitors Of Virion Release
Immune Response Against Viral Pathogens
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
Encephalitis ll: Pathophysiology
Viral Meningitis
Diphtheria