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Updated: Jun 19, 2026

Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting

Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting

Published on: November 30, 2015

A QUANTITATIVE TECHNIQUE FOR PERFORMING PLASMAPHERESIS.

D Melnick¹, G R Cowgill,

¹Laboratory of Physiological Chemistry, Yale University, New Haven.

The Journal of Experimental Medicine

|October 30, 2009

Summary

This summary is machine-generated.

This study introduces a new apparatus and technique for precise quantitative plasmapheresis. It validates methods for calculating blood volume and serum protein concentration needed for safe blood withdrawal.

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Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting

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Preparation of Peripheral Blood Mononuclear Cell Pellets and Plasma from a Single Blood Draw at Clinical Trial Sites for Biomarker Analysis

Preparation of Peripheral Blood Mononuclear Cell Pellets and Plasma from a Single Blood Draw at Clinical Trial Sites for Biomarker Analysis

Published on: March 20, 2021

Area of Science:

Biomedical Engineering
Clinical Pathology
Hematology

Background:

Plasmapheresis requires accurate blood volume and serum protein measurements.
Existing methods may lack precision for quantitative procedures.

Purpose of the Study:

To describe a novel apparatus and technique for quantitative plasmapheresis.
To validate methods for determining essential parameters for plasmapheresis procedures.

Main Methods:

Development of a specialized apparatus for quantitative plasmapheresis.
Application of validated techniques for serum protein concentration determination.
Calculation of blood volume for precise blood withdrawal.

Main Results:

The described apparatus and technique enable quantitative plasmapheresis.
Validated methods ensure accurate determination of serum protein and blood volume.
Precise calculation of blood to be withdrawn is achievable.

Conclusions:

The novel apparatus and technique offer a reliable method for quantitative plasmapheresis.
Accurate prerequisite measurements are crucial for the safety and efficacy of plasmapheresis.
This methodology enhances the precision of therapeutic plasma exchange procedures.