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Updated: Jun 19, 2026

An Ex vivo Culture System to Study Thyroid Development
Published on: June 6, 2014
THE CULTURE OF WHOLE ORGANS : III. THE PROBLEM OF ANTIHORMONES STUDIED ON ISOLATED LIVING THYROID GLANDS
1Laboratories of The Rockefeller Institute for Medical Research.
Abstract:
1. Perfusion of isolated thyroid glands from rabbits, made refractory to the action of the thyro-stimulating factor from the hypophysis by repeated injections for 2 months, has shown that in this condition the thyroid epithelium responds to pituitary stimulation. 2. The serum from refractory rabbits does not neutralize completely the thyro-stimulating effect of anterior pituitary extract upon an isolated normal thyroid gland. 3. It is believed that tissues other than the thyroid play a rôle in bringing about the phenomena which have been described as refractoriness against a prolonged action of the thyro-stimulating pituitary factor.
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