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THE RETICULO-ENDOTHELIAL SYSTEM AND HORMONE REFRACTORINESS.
A S Gordon1, W Kleinberg, H A Charipper
1Department of Biology, Washington Square College, New York University, New York.
The Journal of Experimental Medicine
|October 30, 2009
Summary
The spleen and reticulo-endothelial system influence hormone responses. Removing the spleen or impairing the reticulo-endothelial system enhances ovarian and thyroid activity, suggesting their role in producing antihormone substances.
Area of Science:
- Endocrinology
- Immunology
- Physiology
Background:
- The spleen and reticulo-endothelial system (RES) play crucial roles in immune function and homeostasis.
- Hormonal regulation is complex and can be influenced by various physiological factors.
- Antihormone substances are known to modulate the effects of administered hormones.
Purpose of the Study:
- To investigate the influence of the spleen and RES on hormonal responses in rats and guinea pigs.
- To determine if the RES participates in the production of antihormone substances.
- To explore the relationship between RES integrity and reproductive and thyroid hormone sensitivity.
Main Methods:
- Spleen removal (splenectomy) and RES blockade using trypan blue in rats and guinea pigs.
- Administration of pregnant mare's serum and pregnancy urine extract to assess ovarian, testicular, and seminal vesicle responses.
- Injection of thyrotropic extract to evaluate thyroid function.
- Plasma analysis for antihormone substance levels.
Main Results:
- Splenectomized rats showed increased ovarian weight response to pregnant mare's serum compared to normal rats.
- RES blockade with trypan blue prevented ovarian weight regression in splenectomized rats.
- Bartonella muris infection (injuring RES) also enhanced ovarian response to pregnant mare's serum.
- Similar effects were observed on male reproductive organs and thyroids in splenectomized/RES-impaired animals.
- Plasmatic antihormone substance levels were lower in splenectomized and RES-blocked animals.
Conclusions:
- The reticulo-endothelial system is implicated in the production of antihormone substances.
- Spleen and RES integrity significantly modulate the body's response to exogenous hormones.
- Disruption of the spleen or RES can lead to enhanced sensitivity to reproductive and thyroid hormones.
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