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Updated: Jun 19, 2026
Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits (Oryctolagus cuniculus)
Published on: July 31, 2021
THE EFFECT OF SULFAPYRIDINE UPON THE DEVELOPMENT OF IMMUNITY TO PNEUMOCOCCUS IN RABBITS
1Hospital of The Rockefeller Institute for Medical Research.
Abstract:
1. Sulfapyridine, administered to rabbits during the period of developing immunity after a single intravenous injection of heat-killed Pneumococcus Type I, exerted no influence upon the immune response. 2. Active immunity as indicated by increased resistance to homologous intradermal infection was present 48 hours after the immunizing injection and 2 days before circulating type specific antibodies were detectable. 3. Of the serological techniques employed for the detection of circulating antibody the mouse protective test yielded the highest percentage of positive results followed in order by tests for type specific agglutinins and precipitins, the latter being least satisfactory for the detection of small amounts of antibody.
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