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Updated: Jun 19, 2026

Assessment of the Cytotoxic and Immunomodulatory Effects of Substances in Human Precision-cut Lung Slices
Published on: May 9, 2018
THE SPECIFIC POLYSACCHARIDE CONTENT OF PNEUMONIC LUNGS
A W Frisch1, J T Tripp, C D Barrett
1Departments of Bacteriology and Clinical Pathology, College of Medicine' Wayne University, Detroit, and the Michigan Department of Health Laboratories, Lansing.
Abstract:
1. The specific polysaccharide content of pneumonic lungs in Type III pneumonia was 60 times greater than in Type I, II, VII, and VIII cases. 2. The highest values were obtained from gray hepatized lobes, but the red hepatized and edematous areas also contained large quantities of S. 3. Comparable yields of polysaccharide were recovered from the sputa and lungs of fatal cases. 4. Preliminary peptic digest of lung exudates increased the S yields. 5. The data support the hypothesis that the outcome in Type III pneumonia is related to the ability of the pneumococci to produce capsular polysaccharide.
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