Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bacterial Gastroenteritis

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...

Poliomyelitis

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...

Viral Meningitis

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...

Respiratory Syncytial Virus Disease

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...

Bacterial Meningitis

Bacterial Meningitis

Bacterial meningitis is a severe infectious disease involving inflammation of the meninges, the protective membranes surrounding the brain and spinal cord. It occurs when pathogenic bacteria cross the blood–brain barrier and enter the cerebrospinal fluid. Common causative organisms include Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type b, Listeria monocytogenes, and Escherichia coli K1. The exact route of entry varies by pathogen and host condition.Routes of Entry...

Arboviral Encephalitis

Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Author Correction: Continued Atlantic overturning circulation even under climate extremes.

Nature·2025

Same author

Continued Atlantic overturning circulation even under climate extremes.

Nature·2025

Same author

Timing of Infections in the Threespine Stickleback (Gasterosteus aculeatus) by Schistocephalus solidus in Alaska.

The Journal of parasitology·2015

Same author

Life-history plasticity in female threespine stickleback.

Heredity·2015

Same author

Iterative development and the scope for plasticity: contrasts among trait categories in an adaptive radiation.

Heredity·2015

Same author

Platinum stable isotope analysis of geological standard reference materials by double-spike MC-ICPMS.

Chemical geology·2015

Search research articles

Related Experiment Video

Updated: Jun 19, 2026

The Bovine Lung in Biomedical Research: Visually Guided Bronchoscopy, Intrabronchial Inoculation and In Vivo Sampling Techniques

The Bovine Lung in Biomedical Research: Visually Guided Bronchoscopy, Intrabronchial Inoculation and In Vivo Sampling Techniques

Published on: July 3, 2014

A FILTERABLE VIRUS CAUSING ENTERITIS AND PNEUMONIA IN CALVES.

¹Department of Animal and Plant Pathology of The Rockefeller Institute for Medical Research, Princeton, New Jersey.

The Journal of Experimental Medicine

|October 30, 2009

Summary

This summary is machine-generated.

A novel infectious disease affecting calves, characterized by fever, diarrhea, and pneumonia, has been identified. The causative agent is a filterable virus, transmissible between calves and mice, and neutralized by recovered animal serum.

More Related Videos

Glass Wool Filters for Concentrating Waterborne Viruses and Agricultural Zoonotic Pathogens

Glass Wool Filters for Concentrating Waterborne Viruses and Agricultural Zoonotic Pathogens

Published on: March 3, 2012

Production and Purification of Non Replicative Canine Adenovirus Type 2 Derived Vectors

Production and Purification of Non Replicative Canine Adenovirus Type 2 Derived Vectors

Published on: December 3, 2013

Related Experiment Videos

Last Updated: Jun 19, 2026

The Bovine Lung in Biomedical Research: Visually Guided Bronchoscopy, Intrabronchial Inoculation and In Vivo Sampling Techniques

The Bovine Lung in Biomedical Research: Visually Guided Bronchoscopy, Intrabronchial Inoculation and In Vivo Sampling Techniques

Published on: July 3, 2014

Glass Wool Filters for Concentrating Waterborne Viruses and Agricultural Zoonotic Pathogens

Glass Wool Filters for Concentrating Waterborne Viruses and Agricultural Zoonotic Pathogens

Published on: March 3, 2012

Production and Purification of Non Replicative Canine Adenovirus Type 2 Derived Vectors

Production and Purification of Non Replicative Canine Adenovirus Type 2 Derived Vectors

Published on: December 3, 2013

Area of Science:

Veterinary Medicine
Virology
Infectious Diseases

Background:

A distinct infectious disease in calves presents with fever, diarrhea, and pneumonia.
Autopsies reveal catarrhal enteritis and bronchopneumonia, primarily in anterior lung lobes.

Purpose of the Study:

To identify the causative agent of the described calf infectious disease.
To characterize the transmission and immunological properties of the infectious agent.

Main Methods:

Serial inoculation of lung extracts into mice to isolate the agent.
Intranasal and intratracheal inoculation of calves with mouse-passed material.
Transmission studies via pen contact and serum neutralization tests.

Main Results:

Lung extracts from infected calves produced pneumonia in mice.
Mouse-passed material induced similar disease symptoms in calves, including fever, diarrhea, and pneumonia.
The agent was filterable through Berkefeld N filters and present systemically at the height of infection.
Recovered calves demonstrated resistance to subsequent infection and produced neutralizing antibodies.

Conclusions:

The calf infectious disease is caused by a filterable virus.
The virus is transmissible between calves and mice, with recovered animals developing immunity.