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NON-PARALYTIC POLIOMYELITIS IN THE CHIMPANZEE
1Poliomyelitis Research Center, Department of Epidemiology, Johns Hopkins University, Baltimore.
The Journal of Experimental Medicine
|October 30, 2009
Summary
Non-paralytic poliomyelitis in chimpanzees shows central nervous system lesions, indicating virus action. This suggests potential partial resistance to reinfection, even in mild or inapparent cases.
Area of Science:
- Virology
- Neurology
- Primate Research
Background:
- Poliomyelitis is a viral disease that can affect the central nervous system.
- Understanding the pathological effects of non-paralytic polio is crucial for assessing potential immunity.
Purpose of the Study:
- To describe thirteen cases of non-paralytic poliomyelitis infection in chimpanzees.
- To investigate the presence and distribution of lesions in the central nervous system.
- To evaluate the possibility of partial resistance to reinfection following non-paralytic polio.
Main Methods:
- Observation and description of thirteen experimentally infected chimpanzees.
- Necropsy and histological examination of brain and spinal cord tissues.
- Virus isolation from stool samples.
Main Results:
- All infected chimpanzees exhibited brain lesions compatible with poliomyelitic infection; two also had spinal cord lesions.
- No lesions were found in control chimpanzees, confirming the etiological role of the virus.
- Four cases demonstrated arrest of pathological processes, suggesting partial resistance.
Conclusions:
- Non-paralytic poliomyelitis involves central nervous system lesions, indicating viral activity.
- The presence of lesions suggests the possibility of developing local resistance.
- The degree of pathological involvement varies, implying variable protection against homologous reinfection.
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