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Production of Apolipoprotein C-III Knockout Rabbits using Zinc Finger Nucleases
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HEREDITARY ACHONDROPLASIA IN THE RABBIT : III. GENETIC ASPECTS; GENERAL CONSIDERATIONS

L Pearce1, W H Brown

  • 1Department of Animal and Plant Pathology of The Rockefeller Instutute for Medical Research, Princeton, New Jersey.

The Journal of Experimental Medicine
|October 30, 2009
PubMed

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Epistasis

In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...
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Epistasis Analysis

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