CHEMICAL STUDIES ON HOST-VIRUS INTERACTIONS : I. THE EFFECT OF BACTERIOPHAGE ADSORPTION ON THE MULTIPLICATION OF ITS HOST, ESCHERICHIA COLI B WITH AN APPENDIX GIVING SOME DATA ON THE COMPOSITION OF THE BACTERIOPHAGE, T2
Related Experiment Video
Updated: Jun 19, 2026

T4 Bacteriophage and E. coli Interaction in the Murine Intestine: A Prototypical Model for Studying Host-Bacteriophage Dynamics In Vivo
Published on: January 26, 2024
1Department of Pediatrics, The Children's Hospital of Philadelphia, and the Johnson Research Foundation, University of Pennsylvania, Philadelphia.
Abstract:
The addition of active or irradiated T2 bacteriophage and T4 bacteriophage to E. coli B stops bacterial multiplication. The respiratory rate and respiratory quotient of the inhibited bacteria remained at the values observed just before infection. A respiratory rate decrease which occasionally appears can be roughly correlated with change of turbidity of the suspension. An intracellular inhibitor of multiplication appears to be liberated into lysates. A similar substance has been separated from normal E. coli B after sonic disintegration. These bacteriostatic preparations contain cytoplasmic granules with lactic acid dehydrogenase activity. The relationship of these phenomena to the interference effect in this system and others has been considered.
Related Concept Videos
Viral Replication: Lytic Cycle
DNA Bacteriophages
Bacteriophages of the Human Virome
Lytic Cycle of Bacteriophages
Lysogenic Cycle of Bacteriophages
Viral Replication: Lysogenic Cycle

