Related Experiment Video
Updated: Jun 19, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
Published on: August 12, 2017
TOLERANCE TO BACTERIAL PYROGENS : II. ROLE OF THE RETICULO-ENDOTHELIAL SYSTEM
1Medical Service, Grady Hospital, and the Department of Medicine, Emory University School of Medicine, Atlanta.
Abstract:
IN EXPERIMENTS DESIGNED TO ELUCIDATE THE MECHANISM BY WHICH TOLERANCE TO BACTERIAL PYROGENS IS DEVELOPED, THE FOLLOWING OBSERVATIONS WERE MADE: 1. Animals whose febrile reactions to bacterial pyrogens were markedly diminished, as a result of repeated injections, showed increases in response following R-E blockade. 2. Pyrogenic substances disappeared from the circulating blood more rapidly in rabbits rendered pyrogen-tolerant than in normal animals. Lack of specificity was shown by the fact that rabbits previously injected with Eberthella typhosa bacterial vaccine were able to remove the pyrogens of Serratia marcescens and Pseudomonas aeruginosa from their blood more rapidly than normal animals. 3. R-E blockade-retarded the speed of disappearance of pyrogens from the circulating blood of animals which had been rendered relatively tolerant by previous injections of these substances. A possible mechanism for the development of unresponsiveness to bacterial pyrogens is suggested.
Related Concept Videos
Defense Against Bacterial Pathogens
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Gastritis II: Pathophysiology
Special Features of Adaptive Immunity
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Hypersensitivity Reactions: Cytolytic Reactions
Antigens Involved in Adaptive Immunity
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.

