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Related Experiment Video

Updated: Jun 19, 2026

The Antihypertensive Effects and Mechanisms of Huotan Jiedu Tongluo Decoction in Rats with H-Type Hypertension
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STUDIES ON PLANT HYPERTENSINASE.

F Gollan1, E Richardson, H Goldblatt

  • 1Institute of Pathology, Western Reserve University, Cleveland.

The Journal of Experimental Medicine
|October 30, 2009
PubMed
Summary

Plant-derived hypertensinase from wheat bran effectively lowers blood pressure in dogs with hypertension when administered intravenously. Intramuscular administration showed poor absorption and no effect on blood pressure.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Physiology

Background:

  • Plants, including wheat bran, possess enzymes with biological properties similar to animal hypertensinase.
  • Hypertensinase plays a role in regulating blood pressure by potentially counteracting hypertensin.

Purpose of the Study:

  • To investigate the properties and efficacy of plant-derived hypertensinase from wheat bran.
  • To determine the effects of plant hypertensinase administration on blood pressure in experimental hypertension models.

Main Methods:

  • Purification of hypertensinase from wheat bran using isoelectric and ammonium sulfate precipitation.
  • Administration of plant hypertensinase via intramuscular and intravenous routes in dogs with experimental renal hypertension.
  • Measurement of plasma hypertensinase levels and blood pressure responses to plant hypertensinase, renin, and hypertensin.
Keywords:
HYPERTENSINASE

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Main Results:

  • Intramuscular administration of plant hypertensinase resulted in slow absorption and no significant reduction in blood pressure.
  • Intravenous administration of plant hypertensinase increased plasma hypertensinase levels and reduced blood pressure in hypertensive dogs.
  • Elevated plasma hypertensinase levels inhibited the pressor effects of renin and hypertensin.
  • Inactivated plant hypertensinase had no effect on blood pressure or the action of renin and hypertensin.

Conclusions:

  • Plant-derived hypertensinase from wheat bran can effectively reduce blood pressure in experimental hypertension when delivered intravenously.
  • The efficacy of plant hypertensinase is dependent on its concentration in the plasma.
  • Plant hypertensinase shows potential as a therapeutic agent for hypertension, warranting further investigation into its absorption and delivery methods.