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A MURINE VIRUS (JHM) CAUSING DISSEMINATED ENCEPHALOMYELITIS WITH EXTENSIVE DESTRUCTION OF MYELIN : II. PATHOLOGY

O T Bailey1, A M Pappenheimer, F S Cheever

  • 1Departments of Bacteriology and Pathology, Harvard Medical School, the Neurological Institute of the Children's Hospital, and the Massachusetts Department of Public Health, Boston.

The Journal of Experimental Medicine
|October 30, 2009
PubMed

Insights

This study details experimental encephalomyelitis in mice, revealing widespread myelin destruction and liver necrosis. The findings offer insights into demyelinating diseases in animals and humans.

Area of Science:

  • Virology
  • Neuropathology
  • Comparative Pathology

Background:

  • Spontaneous encephalomyelitis in mice presents unique pathological challenges.
  • Understanding viral-induced central nervous system (CNS) lesions is crucial for disease research.

Purpose of the Study:

  • To characterize the pathological changes induced by a mouse encephalomyelitis virus.
  • To investigate the effects of this virus in various animal models.
  • To compare the induced lesions with known demyelinating diseases.

Main Methods:

  • Experimental inoculation of virus material from spontaneous mouse encephalomyelitis.
  • Histopathological examination of central nervous system, liver, and other organs in mice, hamsters, and rats.
  • Observation of lesion progression and characteristic cellular changes.

Main Results:

  • Widespread myelin destruction in the CNS was the most distinctive feature.
  • Early lesions were characterized by giant cells; focal liver necrosis was common.
  • Massive liver necrosis, fat infiltration, and calcification occurred with high-dose intravenous inoculation.
  • Lesions were reproducible in hamsters; rats exhibited chronic disease patterns.
  • No inclusions or elementary bodies were detected in the lesions.

Conclusions:

  • The mouse encephalomyelitis virus induces significant demyelination and hepatic pathology.
  • Animal models, including hamsters and rats, show varied responses to the virus.
  • The observed pathology provides a basis for understanding related demyelinating diseases.

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