Related Experiment Video
Updated: Jun 19, 2026

11:15
Determining the Contribution of the Energy Systems During Exercise
Published on: March 20, 2012
HOMEOSTATIC ADJUSTMENTS AFTER EXERCISE : I. ACID-BASE EQUILIBRIUM OF THE BLOOD.
1Institute of Child Welfare, University of California, Berkeley.
The Journal of General Physiology
|October 30, 2009
Summary
Severe exercise causes significant blood acid-base imbalance in young men, with peak effects delayed post-exertion. Recovery is rapid, outperforming acid ingestion recovery.
Area of Science:
- Exercise Physiology
- Human Physiology
- Biochemistry
Background:
- Understanding the body's response to intense physical activity is crucial for sports science and clinical health.
- Acid-base balance is a fundamental physiological parameter that can be significantly impacted by metabolic stress.
Purpose of the Study:
- To determine the rate of blood acid-base equilibrium displacement and recovery following maximal exertion in young adult males.
- To compare the effects of severe exercise on acid-base balance with those of acidifying agents like ammonium chloride.
Main Methods:
- Young adult males underwent short periods of maximal exertion.
- Blood samples were analyzed to assess acid-base equilibrium parameters.
- Physiological markers including oxygen consumption, respiratory volume, and blood pressure were monitored.
Main Results:
- Severe exercise induced a metabolic acidosis along a fixed acid path, similar to ammonium chloride ingestion.
- Peak acid-base displacement occurred 7-10 minutes post-exercise, after other physiological changes had begun to resolve.
- Exercise-induced acidosis was more profound than that from oral ammonium chloride and recovered approximately 10 times faster.
- Blood pH normalized more rapidly than serum bicarbonate levels post-exercise.
Conclusions:
- Maximal exertion causes a significant, yet transient, displacement of blood acid-base equilibrium in young adult males.
- The recovery from exercise-induced metabolic acidosis is remarkably rapid compared to that from ingested acid loads.
- The physiological response to exercise differs in magnitude and recovery kinetics from that of acid ingestion.
Related Concept Videos
Acid-Base Balance
The human body maintains a narrow pH range regulated through acid-base balance. This balance is crucial as changes in the hydrogen ion concentration can disrupt cell membrane stability, alter protein structures, and change enzyme activities. The normal pH of arterial blood is 7.4, venous blood and interstitial fluid is 7.35, and intracellular fluid averages 7.0.
When the pH of arterial blood rises above 7.45, it results in a condition called alkalosis. Conversely, a drop below 7.35 leads to...
When the pH of arterial blood rises above 7.45, it results in a condition called alkalosis. Conversely, a drop below 7.35 leads to...
Respiratory Regulation of Acid-Base Balance
Respiratory compensation is a vital physiological process that stabilizes blood plasma pH by regulating the partial pressure of carbon dioxide (PCO2), a key determinant of pH levels. Most carbon dioxide in the blood dissolves and converts into carbonic acid (H2CO3). It dissociates into hydrogen ions (H+) and bicarbonate ions (HCO3⁻). There is also an inverse relationship between PCO2 and pH.
When carbon dioxide levels increase in the blood, more H+ and HCO3⁻ are produced, leading to a...
When carbon dioxide levels increase in the blood, more H+ and HCO3⁻ are produced, leading to a...
pH Homeostasis
Acid-base homeostasis is essential for maintaining normal physiological activities in humans. The pH of various body fluids is strictly regulated because it is critical for the optimal activity of enzymes involved in metabolic reactions. Enzymes are basically proteins, so, any significant change in pH can affect their structure and activity. In humans, pH is regulated using three primary mechanisms— chemical buffer systems, respiratory regulation, and renal regulation.
Respiratory Regulation of...
Respiratory Regulation of...
Compensation Mechanisms
The human body employs intricate mechanisms to counteract changes in blood pH, preventing conditions like acidosis (pH < 7.35) and alkalosis (pH > 7.45). These compensatory responses aim to restore normal arterial blood pH by engaging respiratory or renal systems, depending on the source of the imbalance.
Respiratory Compensation
This mechanism addresses metabolic-induced pH imbalances by adjusting breathing rates. Respiratory compensation begins within minutes of detecting a pH...
Respiratory Compensation
This mechanism addresses metabolic-induced pH imbalances by adjusting breathing rates. Respiratory compensation begins within minutes of detecting a pH...
Renal Regulation of Acid-Base Balance
Metabolic reactions in the body produce nonvolatile acids, such as sulfuric acid, which generate an acid load of approximately 1 mEq of H+ per kilogram of body weight daily. Excreting H+ in the urine is essential to balance this acid load.
In the kidneys, cells within the proximal convoluted tubules (PCT) and the collecting ducts secrete hydrogen ions (H+) into the tubular fluid. Specifically, in the PCT, Na+/H+ antiporters secrete H+ while reabsorbing Na+.
However, the intercalated cells in...
In the kidneys, cells within the proximal convoluted tubules (PCT) and the collecting ducts secrete hydrogen ions (H+) into the tubular fluid. Specifically, in the PCT, Na+/H+ antiporters secrete H+ while reabsorbing Na+.
However, the intercalated cells in...
Disorders of Acid-Base Balance
The human body maintains a precise pH range of arterial blood between 7.35 and 7.45. Deviations result in either acidosis (pH < 7.35) or alkalosis (pH > 7.45). These conditions are further classified as respiratory or metabolic disorders based on their underlying cause.
Respiratory Acidosis and Alkalosis
Respiratory acidosis occurs due to an increase in the partial pressure of carbon dioxide PCO2 in the blood. It often arises from shallow breathing or impaired gas exchange caused by...
Respiratory Acidosis and Alkalosis
Respiratory acidosis occurs due to an increase in the partial pressure of carbon dioxide PCO2 in the blood. It often arises from shallow breathing or impaired gas exchange caused by...
