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Hypertension and the kidney.
R D Lindeman1, J D Tobin, N W Shock
1National Institute of Aging, Baltimore City Hospitals, MD.
Nephron
|January 1, 1987
Summary
High blood pressure significantly accelerates kidney function decline in normal populations. This study confirms an inverse correlation between mean blood pressure and the rate of creatinine clearance decline over time.
Area of Science:
- Nephrology
- Cardiovascular Medicine
- Gerontology
Background:
- Kidney function naturally declines with age.
- Elevated blood pressure is a known risk factor for kidney disease progression.
Purpose of the Study:
- To longitudinally confirm the inverse correlation between blood pressure and renal function decline in a normal population.
- To investigate the independent effects of age and blood pressure on the rate of decline in creatinine clearance.
Main Methods:
- Longitudinal observation of a normal population.
- Regression analysis to correlate mean blood pressure (MBP) with the rate of decline in creatinine clearance over time (Bcr).
- Multiple regression analysis to assess independent effects of MBP and age on Bcr.
Main Results:
- A statistically significant inverse correlation was found between MBP and Bcr (p < 0.001) in all subjects and normal subjects.
- Both increasing age and higher MBP were independently and significantly associated with a faster rate of renal function decline.
- Age-related changes in MBP did not fully explain the observed decline in renal function.
Conclusions:
- Elevated blood pressure is a significant independent predictor of accelerated kidney function decline, even in individuals without pre-existing kidney disease.
- Managing blood pressure is crucial for preserving renal function and preventing kidney disease progression.
- Both aging and hypertension contribute to the decline in creatinine clearance.