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Published on: November 12, 2020
Structure and Function of the Plasma Membrane : A biochemical perspective
1Section on Cellular Physiology, Laboratory of Biochemistry, National Heart Institute, National Institutes of Health, Bethesda, Maryland 20014.
The Journal of General Physiology
|October 30, 2009
Summary
Classical plasma membrane models face challenges with current data. Alternative lipoprotein subunit models are plausible but unproven, suggesting future research should focus on membrane function and biosynthesis.
Area of Science:
- Biochemistry
- Cell Biology
- Structural Biology
Background:
- The paucimolecular unit membrane model has long been the standard for plasma membrane structure.
- Recent advancements in understanding membrane composition and protein behavior challenge this model.
Purpose of the Study:
- To critically review the paucimolecular unit membrane model.
- To assess its compatibility with current biochemical and biophysical data.
- To explore alternative structural models for the plasma membrane.
Main Methods:
- Literature review and critical analysis of existing data.
- Evaluation of studies on plasma membrane chemical and enzymatic composition.
- Assessment of phospholipid properties, protein conformation, and lipid-protein interactions.
Main Results:
- The classical unit membrane model is not well supported by current data and is difficult to reconcile with new findings.
- Lipoprotein subunit models present a biochemically attractive alternative but remain unproven.
- Existing structural models do not fully explain membrane properties and functions.
Conclusions:
- Direct structural studies alone may not resolve current membrane model discrepancies.
- Further investigation into membrane function and biosynthesis is crucial for advancing our understanding of plasma membrane structure.
- A shift in research focus towards dynamic processes may yield more definitive insights.
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