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[Chemical constituents from Xanthium mongolicum]
Wenzhi Zhang1, Wei Han, Ying Li
1State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, China. wzzhang1968@163.com
Summary
This study identified eight chemical compounds from Xanthium mongolicum, including novel lignins and triterpenes. Some compounds showed potential in hindering intercellular adhesion molecule-1 (ICAM-1) activity.
Area of Science:
- Phytochemistry
- Natural Product Chemistry
- Medicinal Chemistry
Context:
- Xanthium mongolicum is a plant species with potential medicinal properties.
- Understanding its chemical composition is crucial for exploring its therapeutic applications.
Purpose:
- To isolate and elucidate the chemical structures of compounds from Xanthium mongolicum.
- To identify novel compounds and characterize known ones within the plant.
Summary:
- Eight compounds were isolated and identified: four sesquiterpene lactones (xanthatin, xanthinosin, 11alpha, 13-dihydroxanthatin, atractylenolide III), two triterpenes (oleanolic acid, ursolic acid), and two lignins (lignocellulose, balanophonin).
- Compounds 11alpha, 13-dihydroxanthatin, oleanolic acid, ursolic acid, lignocellulose, and balanophonin were isolated from this plant for the first time.
- Sesquiterpene lactones (1-3) demonstrated inhibitory activity against intercellular adhesion molecule-1 (ICAM-1), with compound 3 exhibiting weaker activity.
Impact:
- This research expands the knowledge of Xanthium mongolicum's chemical profile.
- The identification of novel compounds and their bioactivity provides a basis for further pharmacological investigations.
- The findings contribute to the development of new therapeutic agents derived from natural sources.