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Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
Published on: March 26, 2020
High-resolution optical coherence tomography correlates in ischemic radiation retinopathy
Rajiv Raman1, Swakshyar Saumya Pal, Tandava Krishnan
1Shri Bhagwan Mahavir Vitreoretinal Services, Tamil Nadu, India. rajivpgraman@gmail.com
Cutaneous and Ocular Toxicology
|October 31, 2009
Summary
Radiation retinopathy thins inner retinal layers, including the inner plexiform and inner nuclear layers, as seen with spectral domain optical coherence tomography (SD-OCT). Outer retinal layers remained largely unaffected.
Area of Science:
- Ophthalmology
- Medical Imaging
- Radiation Oncology
Background:
- Radiation retinopathy is a known complication of radiotherapy involving the eye.
- Early detection of retinal changes is crucial for managing vision loss.
Observation:
- Spectral domain optical coherence tomography (SD-OCT) was used to image radiation retinopathy.
- Analysis focused on foveal and parafoveal retinal layers.
Findings:
- Significant thinning was observed in the inner plexiform layer, inner nuclear layer, and outer plexiform layer.
- The nerve fiber layer, outer nuclear layer, outer segment-inner segment junction, and retinal pigment epithelium (RPE) choriocapillaris layer showed comparable thickness to controls.
Implications:
- Radiation-induced damage appears primarily localized to the inner retinal layers.
- Potential for secondary outer retinal changes necessitates further investigation and monitoring.
