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Related Experiment Video

Updated: Jun 19, 2026

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice
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Published on: July 31, 2019

Frontal-lobe mediated behavioral dysfunction in amyotrophic lateral sclerosis.

M Witgert1, A R Salamone, A M Strutt

  • 1Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA.

European Journal of Neurology
|October 31, 2009
PubMed
Summary
This summary is machine-generated.

Frontal-lobe behavioral impairment is common in Amyotrophic Lateral Sclerosis (ALS), affecting nearly 40% of patients. This dysfunction is linked to cognitive decline, impacting decision-making and treatment adherence.

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Area of Science:

  • Neuroscience
  • Neurology
  • Clinical Research

Background:

  • Amyotrophic Lateral Sclerosis (ALS) frequently involves cognitive impairment due to frontal lobe atrophy (40-60% of cases).
  • Understanding behavioral changes associated with frontal lobe dysfunction in ALS is crucial for patient care.

Purpose of the Study:

  • To determine the prevalence of frontal-lobe mediated behavioral impairment in Amyotrophic Lateral Sclerosis (ALS).
  • To investigate the relationship between behavioral and cognitive impairments in ALS patients.

Main Methods:

  • Evaluated 225 sporadic ALS patients for behavioral dysfunction using the Frontal Systems Behavior Scale (FrSBe).
  • Assessed apathy, executive dysfunction, and disinhibition via FrSBe.
  • A subset of patients underwent comprehensive neuropsychological evaluation.

Main Results:

  • 24.4% of ALS patients showed altered FrSBe scores; 39.6% had impairment in at least one behavioral domain.
  • Apathy was the most common behavioral symptom (31.1%).
  • Cognitively impaired ALS patients exhibited worse overall and apathy scores; however, behavioral dysfunction also occurred in cognitively intact individuals.

Conclusions:

  • Frontal-lobe mediated behavioral dysfunction is prevalent in ALS.
  • Behavioral and cognitive impairments are interconnected in ALS.
  • Identifying these dysfunctions aids in managing decision-making capacity and treatment compliance.