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Bone health in HIV infection
Emily Pollock1, Angelos-Emmanouil Klotsas, Juliet Compston
1Clinical School of Medicine, University of Cambridge, Cambridge, UK.
Introduction:
Osteoporosis is among the chronic problems emerging as the human immunodeficiency virus (HIV)-positive population ages.
Sources Of Data:
We reviewed the English language bibliography using Pubmed 2.0, Web of Science and Embase for relevant abstracts and articles.
Areas Of Agreement:
The prevalence of low bone mineral density (BMD) and fracture is increased in the HIV-positive population.
Areas Of Controversy:
The pathogenesis is multifactorial; there is some evidence that HIV infection is an independent risk factor and that highly active antiretroviral therapy has adverse skeletal effects.
Growing Points:
Physicians should routinely review the bone health of all HIV patients.
Areas Timely For Developing Research:
More studies of the mechanisms of bone loss, the skeletal effects of antiretroviral therapy and the therapeutic outcome of bone-protective therapy in HIV-positive individuals are needed.
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