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Molecular prognosticators of complex karyotype soft tissue sarcoma outcome: a tissue microarray-based study.

G Lahat¹, D Tuvin, C Wei

¹Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Annals of Oncology : Official Journal of the European Society for Medical Oncology

|October 31, 2009

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Researchers identified matrix metalloproteinase (MMP) 2 and nuclear p53 as potential prognostic biomarkers for soft tissue sarcoma (STS). These markers, along with age, location, and grade, predict patient survival and recurrence risk.

Area of Science:

Oncology
Biomarker Discovery
Cancer Research

Background:

Molecular markers are crucial for predicting cancer patient outcomes.
Complex karyotype soft tissue sarcoma (STS) requires novel prognostic biomarkers.

Purpose of the Study:

To identify prognostic biomarkers for complex karyotype soft tissue sarcoma (STS).
To evaluate the correlation of clinicopathological and molecular variables with overall survival (OS) and local recurrence in STS.

Main Methods:

Construction and immunostaining of a large (n=205) clinically annotated tissue microarray (TMA).
Automated image analysis for staining scoring.
Statistical analysis to correlate variables with OS and local recurrence.

Main Results:

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Older age, nonextremity location, high tumor grade, and increased matrix metalloproteinase (MMP) 2 expression predicted poor OS.
Older age, nonextremity location, and increased MMP2 expression correlated with shorter local recurrence-free interval.
High nuclear p53 expression showed a trend toward association with shorter local recurrence-free interval.

Conclusions:

A clinically annotated TMA is effective for identifying STS prognostic markers.
MMP2 and nuclear p53 warrant further evaluation for inclusion in STS staging systems.