Related Experiment Video
Updated: Jun 19, 2026

Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery
Published on: May 16, 2021
Can literature analysis identify innovation drivers in drug discovery?
Pankaj Agarwal1, David B Searls
1Computational Biology Department, GlaxoSmithKline Pharmaceuticals, 709 Swedeland Road, PO BOX 1539, King of Prussia, Pennsylvania 19406, USA. Pankaj.Agarwal@gsk.com
Abstract:
Drug discovery must be guided not only by medical need and commercial potential, but also by the areas in which new science is creating therapeutic opportunities, such as target identification and the understanding of disease mechanisms. To systematically identify such areas of high scientific activity, we use bibliometrics and related data-mining methods to analyse over half a terabyte of data, including PubMed abstracts, literature citation data and patent filings. These analyses reveal trends in scientific activity related to disease studied at varying levels, down to individual genes and pathways, and provide methods to monitor areas in which scientific advances are likely to create new therapeutic opportunities.
Related Concept Videos
Drug Discovery: Overview
Structure-Activity Relationships and Drug Design
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence its...
Pharmacogenomics: Identification of New Drug Targets
Biopharmaceutical Factors Influencing Drug Product Design: Overview
Factors Affecting Drug Response: Overview
Therapeutic Drug Monitoring: Drug Analysis Methods
