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Published on: October 4, 2021
Zigadenus poisoning treated with atropine and dopamine
Patrick West1, B Zane Horowitz
1Oregon Health and Science University, Oregon Poison Center, Portland, OR 97239, USA. westp@ohsu.edu
Summary
Zigadenus (death camas) ingestion can cause severe hypotension and bradycardia. Dopamine infusion effectively stabilized heart rate and blood pressure in a patient, offering a potential treatment for this poisoning.
Area of Science:
- Toxicology
- Cardiology
- Emergency Medicine
Background:
- Zigadenus, or death camas, is a lily family plant found in the US.
- Its appearance can be confused with edible plants like wild onion.
- Ingestion can lead to dangerous hemodynamic instability.
Observation:
- A 45-year-old male ingested Zigadenus bulbs, presenting with nausea, vomiting, hypotension, and bradycardia.
- Initial treatment with IV fluids and atropine provided temporary relief.
- A subsequent drop in vital signs necessitated further intervention.
Findings:
- Dopamine infusion was successfully administered to treat persistent hypotension and bradycardia.
- Atropine provided short-term hemodynamic stabilization (1-2 hours).
- Dopamine effectively stabilized both heart rate and blood pressure.
Implications:
- Zigadenus poisoning requires prompt recognition and management of hemodynamic instability.
- Dopamine infusion is a viable therapeutic option for severe cases.
- Patients typically recover within 24 hours with supportive care, with no known long-term effects.
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