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Less frequent lithium administration and lower urine volume
The American Journal of Psychiatry
|February 1, 1991
Summary
Administering lithium once daily significantly reduces urine volume in patients compared to multiple daily doses. This dosing adjustment can help manage lithium-induced polyuria.
Area of Science:
- Nephrology
- Pharmacology
- Psychiatry
Background:
- Lithium is a common mood stabilizer for bipolar disorder.
- Lithium treatment can lead to increased urine volume (polyuria).
- The impact of lithium dosing schedules on urine volume requires further investigation.
Purpose of the Study:
- To compare urine volumes in patients receiving once-daily lithium versus multiple daily doses.
- To determine if lithium dosing affects urine volume, osmolality, and creatinine clearance.
Main Methods:
- Cross-sectional study of 85 patients at a lithium clinic.
- In-hospital measurements included lithium levels, creatinine clearance, urine volume, and maximum osmolality.
- Patients were categorized by their lithium dosing schedules.
Main Results:
- Patients on multiple daily lithium doses had significantly higher urine volumes.
- Dosing schedule, treatment duration, and daily dose did not impact maximum osmolality.
- Creatinine clearance remained unaffected by lithium dosing parameters.
Conclusions:
- Administering lithium once daily can reduce urine volume.
- Lowering the total daily lithium dose may also decrease polyuria.
- Lithium-induced polyuria appears to involve both renal and extrarenal factors.