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Cyclic anaphylaxis associated with menstruation.

M Burstein1, A Rubinow, M Shalit

  • 1Hadassah University Hospital, Jerusalem, Israel.

Annals of Allergy
|January 1, 1991
PubMed
Summary
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A woman experienced severe anaphylaxis linked to menstruation. Surgical removal of reproductive organs resolved the life-threatening allergic reactions, suggesting a hormonal cause.

Area of Science:

  • Reproductive endocrinology
  • Allergy and immunology
  • Gynecologic surgery

Background:

  • Anaphylaxis is a severe, potentially life-threatening allergic reaction.
  • Menstrual cycle-associated conditions can present with diverse gynecological and systemic symptoms.

Observation:

  • A middle-aged woman presented with recurrent, severe anaphylaxis episodes.
  • These episodes consistently coincided with the onset of her menstrual period.

Findings:

  • Temporary symptom relief was noted with indomethacin, a prostaglandin inhibitor.
  • Complete resolution of anaphylaxis occurred after a total abdominal hysterectomy and bilateral salpingo-oophorectomy.

Implications:

  • This case suggests a potential role for sex hormones and prostaglandin F2 alpha in menstrual anaphylaxis.

Related Experiment Videos

  • Surgical intervention targeting reproductive organs may be a viable treatment for specific anaphylaxis subtypes.