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Related Concept Videos

Cerebrum: Anatomical Overview II01:11

Cerebrum: Anatomical Overview II

Each cerebral hemisphere can be divided into three main regions. The outermost region, the cerebral cortex, is a thin layer (2 to 4 millimeters thick) made up of gray matter, consisting of neuron cell bodies, dendrites, glial cells, and blood vessels. The middle region, or white matter, is primarily composed of myelinated nerve fibers organized into three types of large tracts: association fibers, commissures, and projection fibers. Association fibers connect different areas within the same...
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Related Experiment Video

Updated: Jun 19, 2026

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

White matter microstructure underlying default mode network connectivity in the human brain.

Stefan J Teipel1, Arun L W Bokde, Thomas Meindl

  • 1Department of Psychiatry, University Rostock, Rostock, Germany.

Neuroimage
|November 3, 2009
PubMed
Summary
This summary is machine-generated.

This study links brain connectivity patterns in the default mode network (DMN) to white matter structure. Findings show that functional connections in the DMN are supported by specific anatomical pathways in the brain's white matter.

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Combining Transcranial Magnetic Stimulation and fMRI to Examine the Default Mode Network

Published on: December 28, 2010

Area of Science:

  • Neuroimaging
  • Neuroscience
  • Brain Connectivity

Background:

  • Resting state functional magnetic resonance imaging (fMRI) identifies the brain's default mode network (DMN).
  • The structural basis of DMN functional connectivity, particularly white matter integrity, remains largely unexplored.

Purpose of the Study:

  • To investigate the relationship between white matter microstructure and default mode network (DMN) functional connectivity.
  • To identify specific white matter tracts associated with functional connectivity between the posterior cingulate and hippocampus within the DMN.

Main Methods:

  • Combined diffusion tensor imaging (DTI) for white matter integrity and resting state fMRI data from 20 healthy elderly adults.
  • Employed voxel-based multivariate analysis of covariance (MANCOVA) and joint independent component analysis (ICA) to link structural and functional data.

Main Results:

  • Demonstrated a significant association (p<0.001) between functional connectivity in the DMN and white matter microstructure in the cingulate bundle and connecting tracts.
  • ICA revealed patterns of white matter tracts, including the cingulate bundle, that corresponded to DMN functional connectivity.

Conclusions:

  • Functional connectivity within the default mode network (DMN), including the posterior cingulate and hippocampus, is underpinned by specific anatomical connections in the brain's white matter.
  • Findings support a strong link between white matter structural integrity and the functional organization of the DMN.