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Reticular macular disease.

R Theodore Smith1, Mahsa A Sohrab, Mihai Busuioc

  • 1Department of Ophthalmology, Columbia University, New York, NY 10032, USA. rts1@columbia.edu

American Journal of Ophthalmology
|November 3, 2009
PubMed
Summary
This summary is machine-generated.

Reticular macular disease (RMD), including reticular pseudodrusen (RPD), is a single entity with consistent imaging findings. It is linked to advanced age-related macular degeneration, possibly due to inflammation.

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Area of Science:

  • Ophthalmology
  • Retinal Imaging
  • Macular Degeneration

Background:

  • Reticular macular disease (RMD) is a common clinical finding.
  • It is associated with reticular pseudodrusen (RPD).
  • RMD confers a high risk of progression to advanced age-related macular degeneration (AMD).

Purpose of the Study:

  • To provide a unified description of reticular macular disease (RMD).
  • To highlight its association with reticular pseudodrusen (RPD).
  • To emphasize its role as a risk factor for advanced AMD.

Main Methods:

  • Retrospective, population-based study of 42 patients with reticular findings.
  • RMD defined by RPD on photography and reticular patterns on scanning laser ophthalmoscopy (SLO).
  • Imaging methods included color, red-free, autofluorescence, infrared, and indocyanine green angiography; image registration used for comparison.

Main Results:

  • RMD typically presented across multiple imaging modalities with overlapping or nested areas.
  • Individual lesions showed high spatial correspondence between imaging methods.
  • Serial imaging revealed fading or absence of RMD findings in eyes that developed choroidal neovascularization.

Conclusions:

  • Reticular macular disease (RMD) is a singular entity with characteristic presentations across various imaging techniques.
  • Imaging suggests RMD involves the retinal pigment epithelium and choriocapillaris, with photographic patterns implicating the inner choroid.
  • RMD is associated with progression to advanced age-related macular degeneration, potentially mediated by inflammation, and warrants greater clinical recognition.