Related Experiment Videos
[Acute nephrotoxicity by CDDP (on tubular damage)]
K Higuchi1, Y Negoro, M Suzuki
1Department of Obstetrics and Gynecology, Aichi Medical University, Japan.
Gan to Kagaku Ryoho. Cancer & Chemotherapy
|January 1, 1991
Summary
Urinary trehalase can detect early kidney damage from cisplatin (CDDP). Doses under 300 mg show reversible damage, while higher doses indicate irreversible renal tubular injury.
Area of Science:
- Nephrology
- Biochemistry
- Toxicology
Background:
- Cisplatin (CDDP) is a potent chemotherapy agent with known nephrotoxic side effects.
- Assessing acute kidney injury from CDDP is crucial for patient management.
- Urinary trehalase, localized in the renal tubular brush border, presents a potential biomarker for nephrotoxicity.