Left atrial volume index: a predictor of adverse outcome in patients with hypertrophic cardiomyopathy

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Woo-In Yang1, Chi Young Shim, Young Jin Kim

  • 1Cardiology Division, Cardiovascular Center, Yonsei University College of Medicine, Seoul, Korea.

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
|November 3, 2009
PubMed

Insights

Left atrial volume index predicts adverse outcomes in hypertrophic cardiomyopathy (HCM) patients, including heart failure hospitalizations and stroke. This key metric offers valuable prognostic information for managing HCM risks.

Area of Science:

  • Cardiology
  • Cardiovascular Imaging
  • Heart Failure Research

Background:

  • Hypertrophic cardiomyopathy (HCM) can lead to sudden cardiac death and heart failure (HF).
  • Predicting adverse outcomes in HCM is crucial for patient management.
  • Identifying reliable prognostic markers in HCM is an ongoing clinical need.

Purpose of the Study:

  • To identify predictive parameters for adverse outcomes in nonapical hypertrophic cardiomyopathy (HCM).
  • To evaluate echocardiographic, cardiac magnetic resonance (CMR), and clinical markers for risk stratification.
  • To determine the prognostic value of left atrial (LA) volume index in HCM.

Main Methods:

  • Prospective evaluation of 81 nonapical HCM patients (51 male, mean age 57 years).
  • Patients underwent cardiac magnetic resonance (CMR) and echocardiography.
  • Cardiovascular events included HF hospitalization, stroke, or cardiovascular death over a mean follow-up of 41 months.

Main Results:

  • Seventeen cardiovascular events occurred during follow-up.
  • Univariate analysis identified age, atrial fibrillation, E/E' ratio, LA volume index, mitral regurgitation, NYHA class, and late gadolinium enhancement as associated with events.
  • Multivariate analysis revealed increased LA volume index as an independent predictor of cardiovascular events (HR 1.28 per 5 mL/m(2) increase) and non-death events (HR 1.44 per 5 mL/m(2) increase).

Conclusions:

  • Left atrial (LA) volume index is an independent predictor of adverse outcomes in hypertrophic cardiomyopathy (HCM).
  • LA volume index provides significant additional prognostic information for HCM patients.
  • This finding aids in risk stratification and management of patients with HCM.
Abstract

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