Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...

Positron Emission Tomography

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...

Imaging Studies IV: Magnetic Resonance Imaging

Imaging Studies IV: Magnetic Resonance Imaging

Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...

Imaging Studies I: CT and MRI

Imaging Studies I: CT and MRI

Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...

Radiological Investigation II: MRI and Ventilation Perfusion Scan

Radiological Investigation II: MRI and Ventilation Perfusion Scan

Description
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
MRI
MRI uses magnetic fields and radiofrequency signals to distinguish between normal and abnormal tissues. This technology provides a more detailed diagnostic image than CT scans, enabling it to characterize pulmonary nodules, stage bronchogenic carcinoma, and evaluate inflammatory activity in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Relationship Between Gastrointestinal Transit, Medsger Gastrointestinal Severity, and University of California-Los Angeles Scleroderma Clinical Trial Consortium Gastrointestinal Tract 2.0 Symptoms in Patients With Systemic Sclerosis.

Arthritis care & research·2020

Same author

Experience with Esophagogastrointestinal Transit Scintigraphy in the Initial 229 Patients: Multiple Regions of Dysmotility Are Common.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2020

Same author

Regarding Pharmacology, Part 3A.

Journal of nuclear medicine technology·2019

Same author

Sincalide: A Review of Clinical Utility, Proper Infusion Methodology, and Alternative Cholecystogogues.

Journal of nuclear medicine technology·2019

Same author

EnsurePlus as an Alternative to the Standardized Egg Gastric-Emptying Meal.

Clinical nuclear medicine·2019

Same author

Nuclear Scintigraphy in Practice: Gastrointestinal Motility.

AJR. American journal of roentgenology·2018

Search research articles

Related Experiment Video

Updated: Jun 19, 2026

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of ⁶⁸Ga-Labelled Nano Molecules

Published on: October 4, 2024

Nuclear medicine hepatobiliary imaging.

Harvey A Ziessman¹

¹Division of Nuclear Medicine, Russell H. Morgan Department of Radiology and Radiologic Science, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA. hziessm1@jhmi.edu

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association

|November 3, 2009

Summary

Hepatobiliary iminodiacetic acid (HIDA) scans diagnose gallbladder and biliary system issues by tracking radiopharmaceuticals. This nuclear medicine technique is crucial for identifying conditions like acute cholecystitis and biliary obstruction.

More Related Videos

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

Published on: November 27, 2016

Non-Invasive PET/MR Imaging in an Orthotopic Mouse Model of Hepatocellular Carcinoma

Non-Invasive PET/MR Imaging in an Orthotopic Mouse Model of Hepatocellular Carcinoma

Published on: August 31, 2022

Related Experiment Videos

Last Updated: Jun 19, 2026

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of ⁶⁸Ga-Labelled Nano Molecules

Published on: October 4, 2024

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

Published on: November 27, 2016

Non-Invasive PET/MR Imaging in an Orthotopic Mouse Model of Hepatocellular Carcinoma

Non-Invasive PET/MR Imaging in an Orthotopic Mouse Model of Hepatocellular Carcinoma

Published on: August 31, 2022

Area of Science:

Nuclear Medicine
Diagnostic Imaging
Hepatobiliary System Physiology

Background:

Hepatobiliary iminodiacetic acid (HIDA) imaging is an established nuclear medicine technique.
It utilizes radiopharmaceuticals processed by hepatocytes and cleared via the biliary system, mirroring bilirubin's pathway.
This method provides physiological insights into liver and biliary function.

Purpose of the Study:

To elucidate the diagnostic capabilities of HIDA imaging in various hepatobiliary conditions.
To highlight HIDA's role in diagnosing acute cholecystitis, biliary obstruction, and gallbladder dysfunction.
To underscore the value of HIDA in post-surgical and transplant evaluations.

Main Methods:

Administration of HIDA radiopharmaceuticals that are taken up by liver cells (hepatocytes).
Utilizing specialized cameras to visualize the uptake, clearance, and flow through the biliary system.
Assessing gallbladder filling, emptying (ejection fraction), and detecting biliary leakage.

Main Results:

HIDA imaging is highly effective for diagnosing acute cholecystitis by identifying non-filling of the gallbladder due to cystic duct obstruction.
It can detect high-grade biliary obstruction before ductal dilation, evidenced by persistent hepatogram and lack of biliary clearance.
The technique aids in diagnosing partial obstructions, biliary leakage post-surgery, and chronic acalculous gallbladder disease via ejection fraction calculation.

Conclusions:

HIDA imaging is a versatile and time-proven diagnostic tool for a wide range of hepatobiliary disorders.
Its physiological basis allows for early detection of obstruction and assessment of gallbladder function.
HIDA scans are invaluable for confirming biliary leakage and evaluating gallbladder ejection fraction, aiding in chronic disease diagnosis.