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Related Concept Videos

Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Bacterial Meningitis01:24

Bacterial Meningitis

Bacterial meningitis is a severe infectious disease involving inflammation of the meninges, the protective membranes surrounding the brain and spinal cord. It occurs when pathogenic bacteria cross the blood–brain barrier and enter the cerebrospinal fluid. Common causative organisms include Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type b, Listeria monocytogenes, and Escherichia coli K1. The exact route of entry varies by pathogen and host condition.Routes of Entry...
SBAR I: Understanding the Concept01:29

SBAR I: Understanding the Concept

Effective communication among healthcare professionals during hand-off reporting is essential to delivering safe and continuous patient care. Common professional interactions include reports to healthcare team members, hand-off, and transfer reports. Nurses routinely report information to other healthcare team members and also urgently contact healthcare providers to report changes in patient status.
Standardized methods of communication have been developed to ensure that information is...
SBAR II: Application of SBAR01:14

SBAR II: Application of SBAR

SBAR is an effective communication tool used by healthcare professionals to communicate patient information accurately. SBAR stands for Situation, Background, Assessment, and Recommendation. For a better understanding, an example is given below.
SBAR Report from a Nurse to a Health Care Provider
S: "Hello, Dr. Smith. This is Jane, RN, from the Med Surg unit. I am calling to tell you about Ms. White in Room 210, who is experiencing increased pain and redness at her incision site. Her recent...

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Related Experiment Video

Updated: Jun 19, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

What is MRSA?

A Pantosti1, M Venditti

  • 1Dept of Infectious, Parasitic and Immune-mediated Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome 00161, Italy. annalisa.pantosti@iss.it

The European Respiratory Journal
|November 3, 2009
PubMed
Summary
This summary is machine-generated.

Methicillin-resistant Staphylococcus aureus (MRSA) has evolved from a hospital-acquired pathogen to causing community infections. Understanding MRSA epidemiology is crucial for effective control strategies.

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Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
14:04

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

Published on: May 8, 2013

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Last Updated: Jun 19, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
14:04

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

Published on: May 8, 2013

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Epidemiology

Background:

  • Methicillin-resistant Staphylococcus aureus (MRSA) is a significant nosocomial pathogen.
  • MRSA has evolved, leading to community-acquired infections (CA-MRSA) in diverse populations.
  • CA-MRSA strains, like USA300 in the US, differ from European clones and often carry Panton-Valentine leukocidin genes.

Purpose of the Study:

  • To review the evolving epidemiology of MRSA.
  • To highlight the transition of MRSA from healthcare settings to the community.
  • To underscore the importance of monitoring MRSA strains and reservoirs.

Main Methods:

  • Literature review of MRSA epidemiology.
  • Analysis of MRSA strain evolution and characteristics.
  • Examination of MRSA's impact on healthcare-associated and community-acquired infections.

Main Results:

  • MRSA now causes infections in patients with and without healthcare contact.
  • Community-acquired MRSA (CA-MRSA) primarily causes skin infections and pneumonia.
  • A significant MRSA reservoir exists in pigs, with implications for occupational exposure.

Conclusions:

  • MRSA's changing epidemiology necessitates continuous surveillance.
  • Understanding CA-MRSA and its transmission is vital for public health.
  • Monitoring animal reservoirs and occupational colonization is essential for MRSA control.