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Second-generation antipsychotic long-acting injections: systematic review
1Medical University Innsbruck, Department of Psychiatry and Psychotherapy, Anichstrasse 35, A-6020 Innsbruck, Austria. wolfgang.fleischhacker@i-med.ac.at
The British Journal of Psychiatry. Supplement
|November 3, 2009
Summary
Second-generation antipsychotic long-acting injections (LAIs) offer effective schizophrenia management. Further long-term comparisons with oral formulations and older LAIs are needed, including cost-effectiveness data.
Area of Science:
- Psychiatry
- Pharmacology
Background:
- Second-generation antipsychotics (SGAs) are crucial for long-term schizophrenia management.
- Long-acting injections (LAIs) represent an advancement in SGA delivery.
Purpose of the Study:
- To review existing evidence on second-generation antipsychotic long-acting injections (SGA-LAIs).
Main Methods:
- A systematic literature review was performed.
- PubMed was utilized as the primary database for the search.
Main Results:
- Risperidone LAI is an effective SGA-LAI for schizophrenia, with a safety profile similar to oral risperidone.
- Olanzapine pamoate shows comparable efficacy to oral olanzapine but requires safety considerations for "post-injection syndrome."
- Paliperidone palmitate offers potential for monthly dosing and is under regulatory review.
Conclusions:
- Long-term comparative studies of SGA-LAIs versus oral SGAs and first-generation antipsychotic LAIs are necessary.
- Future research should incorporate cost-effectiveness analyses for SGA-LAIs.
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