Related Experiment Video
Updated: Jun 19, 2026
09:32
Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
Published on: September 26, 2019
Autologous serum skin test in children
1Shree Skin Centre and Laboratory, 21/22, L Market, Sector 8, Nerul, Navi Mumbai - 400 706, India. drgodse@gmail.com
Indian Journal of Dermatology
|November 3, 2009
Summary
The autologous serum skin test (ASST) can detect autoantibodies in children with chronic urticaria. This simple test showed positive results in 35% of pediatric patients, indicating its utility.
Area of Science:
- Pediatric Dermatology
- Immunology
Background:
- Chronic urticaria (CU) is less common in children than adults.
- Identifying the underlying causes of CU in pediatric patients is crucial for effective management.
Purpose of the Study:
- To evaluate the utility of the autologous serum skin test (ASST) in diagnosing chronic urticaria in children.
- To determine the prevalence of positive ASST results in a pediatric cohort with chronic urticaria.
Main Methods:
- The study included 17 children aged 6-16 years diagnosed with chronic urticaria.
- An autologous serum skin test was performed, comparing wheal and flare reactions to a saline control.
Main Results:
- Six out of 17 children (35%) exhibited a positive ASST result, defined as a wheal and flare reaction exceeding 1.5 mm compared to the saline control.
- The ASST demonstrated a positive response in a significant subset of the pediatric chronic urticaria population.
Conclusions:
- The autologous serum skin test is a valuable, cost-effective, and easily performable diagnostic tool for chronic urticaria in children.
- ASST shows good sensitivity and high specificity for detecting autoantibodies in pediatric patients with chronic urticaria, aiding in diagnosis.
