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[Perioperative antibiotics effectiveness on conjunctival flora and microbial sensitivity]
Yoshikuni Arakaki1, Kazuhisa Hayakawa, Fumihiko Mori
1Department of Clinical Neuroscience, Visual Function and Science, University of the Ryukyus, Faculty of Medicine, Okinawa-ken, Japan. yoshikuni-arakaki@earth.ocn.ne.jp
Nippon Ganka Gakkai Zasshi
|November 4, 2009
Summary
This study compared two gatifloxacin (GFLX) ophthalmic solution instillation methods. While both showed minimal impact on conjunctival bacterial flora, one case of GFLX resistance emerged, highlighting the need for judicious antibiotic use.
Area of Science:
- Ophthalmology
- Microbiology
- Pharmacology
Background:
- Topical antibiotics are frequently used in ophthalmic perioperative periods.
- Understanding their impact on microbial flora and resistance is crucial.
Purpose of the Study:
- To compare the effects of two different gatifloxacin (GFLX) ophthalmic solution instillation regimens on conjunctival sac bacterial flora and microbial sensitivity.
- To prospectively evaluate the influence of GFLX instillation frequency and duration on bacterial resistance patterns.
Main Methods:
- Patients undergoing cataract surgery were divided into two groups.
- Group A received GFLX eight times/day for 2 days, then four times/day for 12 days.
- Group B received GFLX four times/day for 28 days. Bacterial flora and sensitivity were assessed.
Main Results:
- No significant difference was observed in the detection rate of bacterial flora between the two groups.
- One bacterial isolate resistant to levofloxacin (LVFX) was found in Group A.
- One isolate resistant to both GFLX and LVFX was identified in Group B.
Conclusions:
- Topical antibiotic application may have minimal influence on positive bacterial cultures.
- The emergence of GFLX resistance underscores the importance of avoiding indiscriminate antibiotic use in ophthalmic perioperative care.
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