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Related Experiment Video

Updated: Jun 19, 2026

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
08:55

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

Published on: November 30, 2016

Cancer-induced cachexia: a guide for the oncologist.

Norleena Gullett1, Peter Rossi, Omer Kucuk

  • 1Department of Radiation Oncology, Emory University School of Medicine, Atlanta, GA, USA.

Journal of the Society for Integrative Oncology
|November 4, 2009
PubMed
Summary

Cancer-induced cachexia (CIC) is a deadly syndrome causing metabolic changes. Evidence-based management is needed, including assessment, nutritional support, and exploring experimental therapies to combat this condition.

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Area of Science:

  • Oncology
  • Metabolic Syndrome
  • Clinical Nutrition

Background:

  • Cancer-induced cachexia (CIC) is a paraneoplastic syndrome contributing to 20% of cancer deaths.
  • CIC involves metabolic alterations driven by the host's acute-phase response (APR) to tumor cells.
  • Current therapies often fail to address the underlying APR and its metabolic consequences.

Purpose of the Study:

  • To review current data on the assessment of starvation and cachexia.
  • To provide evidence-based guidelines for managing CIC.
  • To review existing and experimental therapies for CIC.

Main Methods:

  • Review of current literature on cancer-induced cachexia.
  • Analysis of data for serum markers and functional assessment in cachexia.
  • Compilation of information on nutritional interventions, appetite stimulants, and experimental treatments.

Main Results:

  • Guidelines for assessment incorporating serum markers and functional status are proposed.
  • Current management strategies include nutritional support and appetite stimulants like corticosteroids.
  • Experimental therapies under investigation include NSAIDs, TNF-alpha antagonists, and omega-3 fatty acids.

Conclusions:

  • Effective management of CIC requires addressing the acute-phase response and its metabolic effects.
  • Evidence-based guidelines are crucial for oncologists managing cachectic patients.
  • Further research into novel therapeutic agents is warranted to improve patient outcomes.