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Nutraceuticals in Uro-Oncology: A Structured Expert Review and Precision-Oriented Framework
Fusun Erten1, Ecem Kalemoglu2, Omer Kucuk3
1Pertek Sakine Genç Vocational School, Munzur University, 62000 Tunceli, Türkiye.
Nutrients
|August 13, 2026
Summary
Food-derived nutraceuticals show potential for urologic malignancies (UMs) by influencing cancer pathways. However, clinical translation is limited by bioavailability and formulation issues, not supporting their use as cancer treatments.
Area of Science:
- Oncology
- Pharmacology
- Nutritional Science
Background:
- Urologic malignancies (UMs) like prostate cancer (PCa) and bladder cancer (BCa) involve complex molecular pathways.
- These pathways include PI3K/AKT/mTOR, VEGF/VEGFR, and androgen receptor signaling, influencing cancer progression and treatment resistance.
Purpose of the Study:
- To review evidence on food- and botanical-derived nutraceuticals' potential effects on cancer-related signaling in UMs.
- To evaluate mechanistic, translational, and clinical data on nutraceuticals as adjunctive exposures, not primary treatments.
Main Methods:
- A structured, non-systematic literature search of major databases (PubMed, Scopus, Web of Science, Embase) up to June 2026.
- Evaluation of preclinical, observational, and interventional studies, focusing on formulation, bioavailability, safety, and interactions.
Main Results:
- Nutraceuticals like curcumin, green tea catechins, and isoflavones impact cancer pathways mainly in experimental models.
- Clinical translation is hindered by inconsistent formulations, poor bioavailability, and lack of exposure data.
Conclusions:
- Current evidence does not support nutraceuticals as treatments for urologic malignancies.
- Future research needs chemically defined formulations, verified exposure, and compatibility with standard therapies.
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