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Updated: Jun 19, 2026

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
Published on: February 7, 2015
Comprehensive noninvasive arterial vascular evaluation
Jay N Cohn1, Daniel A Duprez, Stanley M Finkelstein
1Cardiovascular Division, Mayo Mail Code 508, Minneapolis, MN 55455, USA. cohnx001@umn.edu
Insights
Noninvasive vascular health assessment identifies cardiovascular risk. Pulse-contour analysis offers comprehensive insights into both large and small artery function and structure, aiding therapy monitoring.
Area of Science:
- Cardiovascular science
- Vascular biology
- Medical diagnostics
Background:
- Noninvasive vascular health assessment is crucial for identifying cardiovascular disease risk.
- Endothelial dysfunction significantly impacts small artery function and contributes to vascular changes.
- Current methods like ultrasonography and pulse-wave velocity offer limited insights into large artery structure.
Purpose of the Study:
- To highlight the importance of comprehensive vascular health assessment.
- To introduce pulse-contour analysis as a superior method for evaluating both large and small arteries.
- To emphasize its potential in monitoring therapeutic responses.
Main Methods:
- Review of existing noninvasive vascular assessment techniques.
- Focus on pulse-contour analysis for evaluating arterial function and structure.
- Comparison with ultrasonography and aortic pulse-wave velocity.
Main Results:
- Pulse-contour analysis provides a comprehensive assessment of both large and small arteries.
- It offers insights into functional and structural abnormalities.
- Ultrasonography and pulse-wave velocity are limited to large artery structural changes.
Conclusions:
- Comprehensive assessment of vascular health is best achieved through pulse-contour analysis.
- This method can detect both functional and structural abnormalities in arteries.
- Pulse-contour analysis shows promise for monitoring treatment efficacy in cardiovascular disease.
Abstract:
Noninvasive evaluation of the health of the vasculature is an increasingly important approach to identifying individuals at risk for cardiovascular morbid events. Vascular health assessment involves functional and structural examination of the large and small arteries. Endothelial dysfunction, which alters small artery function, is a key contributor to progressive structural vascular changes. Ultrasonography of conduit arteries and aortic pulse-wave velocity provide information limited to structural changes in large arteries. Comprehensive assessment of the large and small arteries is best carried out by pulse-contour analysis. This can provide insight into functional and structural abnormalities in the small as well as the large arteries, and may be useful in monitoring response to therapy.
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