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Eccrine sweat response in children with asthma

A Oflu1, O U Soyer, A Tuncer

  • 1Hacettepe University School of Medicine, Ankara, Turkey.

Allergy
|November 6, 2009
PubMed

Insights

Asthmatic children, especially boys, exhibit increased sweating after exercise. Anti-inflammatory asthma medication can reduce this sweating response.

Area of Science:

  • Pediatric Pulmonology
  • Dermatology
  • Exercise Physiology

Background:

  • Asthmatic children are widely believed to sweat more than healthy children, but this has not been scientifically validated.
  • Understanding sweating patterns in pediatric asthma is crucial for managing the condition.

Purpose of the Study:

  • To quantify the sweating response to exercise in children with asthma.
  • To identify factors influencing sweating in asthmatic children.
  • To compare sweating responses between asthmatic and healthy children.

Main Methods:

  • Transepidermal water loss (TEWL) was measured in 82 children with asthma and 51 healthy controls (ages 6-18).
  • Measurements were taken on the palms, volar forearms, forehead, and back, both before and after a standardized exercise protocol.
  • TEWL was calculated as the difference between post-exercise and resting measurements.

Main Results:

  • Children with asthma showed significantly higher palmar TEWL post-exercise compared to healthy controls (22.8 vs. 15.2 g/m²h).
  • Increased TEWL was observed in asthmatic boys across all measured surfaces, but not in girls.
  • Asthmatic children on anti-inflammatory therapy had lower TEWL on the volar forearm and back compared to those using only as-needed bronchodilators.

Conclusions:

  • Asthma is linked to an elevated sweating response to exercise, particularly in boys.
  • Anti-inflammatory treatment appears to mitigate the increased sweating observed in asthmatic children.
  • Further research is needed to explore the connection between eccrine sweating, muscarinic receptor response, and methacholine hyperresponsiveness in asthma.
Abstract

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