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Asthma I: Introduction

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

Asthma III: Clinical Manifestations

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...

Asthma-I: Introduction

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

Asthma: Pathogenesis and Management

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

Asthma-III: Symptoms and Complications

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma

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Related Experiment Video

Updated: Jun 19, 2026

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

Eccrine sweat response in children with asthma.

A Oflu¹, O U Soyer, A Tuncer

¹Hacettepe University School of Medicine, Ankara, Turkey.

|November 6, 2009

Summary

Asthmatic children, especially boys, exhibit increased sweating after exercise. Anti-inflammatory asthma medication can reduce this sweating response.

Area of Science:

Pediatric Pulmonology
Dermatology
Exercise Physiology

Background:

Asthmatic children are widely believed to sweat more than healthy children, but this has not been scientifically validated.
Understanding sweating patterns in pediatric asthma is crucial for managing the condition.

Purpose of the Study:

To quantify the sweating response to exercise in children with asthma.
To identify factors influencing sweating in asthmatic children.
To compare sweating responses between asthmatic and healthy children.

Main Methods:

Transepidermal water loss (TEWL) was measured in 82 children with asthma and 51 healthy controls (ages 6-18).
Measurements were taken on the palms, volar forearms, forehead, and back, both before and after a standardized exercise protocol.

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A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

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Published on: June 4, 2017

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Last Updated: Jun 19, 2026

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

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Published on: March 3, 2023

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

TEWL was calculated as the difference between post-exercise and resting measurements.

Main Results:

Children with asthma showed significantly higher palmar TEWL post-exercise compared to healthy controls (22.8 vs. 15.2 g/m²h).
Increased TEWL was observed in asthmatic boys across all measured surfaces, but not in girls.
Asthmatic children on anti-inflammatory therapy had lower TEWL on the volar forearm and back compared to those using only as-needed bronchodilators.

Conclusions:

Asthma is linked to an elevated sweating response to exercise, particularly in boys.
Anti-inflammatory treatment appears to mitigate the increased sweating observed in asthmatic children.
Further research is needed to explore the connection between eccrine sweating, muscarinic receptor response, and methacholine hyperresponsiveness in asthma.