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Updated: Jun 19, 2026
09:02
Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation
Published on: February 15, 2018
Milk induced enterocolitis in monozygotic twin neonates
Misa Watanabe1, Kazutomo Tamaki, Tustomu Saji
1Departments of Pediatrics and Surgery, Toho University School of Medicine, Tokyo, Japan. misa-watanabe@med.toho-u.ac.jp
Indian Pediatrics
|November 6, 2009
Summary
Milk protein-induced enterocolitis is rising, with few twin cases reported. This study details two infant twins diagnosed with this condition after initial misdiagnosis.
Area of Science:
- Pediatrics
- Gastroenterology
- Neonatal Medicine
Background:
- Milk protein-induced enterocolitis is an emerging concern in infants.
- Diagnosis can be challenging, often mimicking surgical or infectious conditions.
- Limited literature exists on this condition specifically in twin infants.
Observation:
- Twin Japanese girls presented with bloody diarrhea on day 4 of life.
- They were admitted to the Neonatal Intensive Care Unit (NICU) for evaluation.
- Initial diagnostic considerations included surgical emergencies and sepsis.
Findings:
- The diagnosis of milk protein-induced enterocolitis was confirmed after 12 days of hospitalization.
- The condition presented similarly in both twins, suggesting a potential shared etiology or trigger.
- Differential diagnoses were systematically excluded to arrive at the correct diagnosis.
Implications:
- This case highlights the importance of considering non-surgical gastrointestinal disorders in neonates with bloody diarrhea.
- Early recognition and diagnosis of milk protein-induced enterocolitis are crucial for appropriate management.
- Further research into the presentation and diagnosis of this condition in twins is warranted.
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