Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Spongy Bone01:09

Spongy Bone

All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
The Bone Matrix01:18

The Bone Matrix

Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Remote analysis and management of sweat biomarkers using a wearable microfluidic sticker in adult cystic fibrosis patients.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Roadmap for animate matter.

Journal of physics. Condensed matter : an Institute of Physics journal·2025
Same author

Remote exercise-induced sweat chloride measurements using a wearable microfluidic sticker in cystic fibrosis patients.

medRxiv : the preprint server for health sciences·2025
Same author

Wearable microfluidic biosensors with haptic feedback for continuous monitoring of hydration biomarkers in workers.

NPJ digital medicine·2025
Same author

A bacteriocin expression platform for targeting pathogenic bacterial species.

Nature communications·2024
Same author

The Development and Characterisation of a P(3HB-<i>co</i>-4HB)-Bioactive Glass-Graphene Hydrogel as a Potential Formulation for Biomedical and Therapeutical Translation.

Gels (Basel, Switzerland)·2024

Related Experiment Video

Updated: Jun 19, 2026

Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection
09:09

Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection

Published on: March 14, 2019

Interaction of staphylococci with bone.

John A Wright1, Sean P Nair

  • 1Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, 256 Gray's Inn Road, London WC1X 8LD, UK.

International Journal of Medical Microbiology : IJMM
|November 6, 2009
PubMed
Summary
This summary is machine-generated.

Staphylococcus aureus causes most bone infections, which are hard to treat due to antibiotic resistance. Understanding how these bacteria damage bone is key to developing new therapies.

Related Experiment Videos

Last Updated: Jun 19, 2026

Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection
09:09

Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection

Published on: March 14, 2019

Area of Science:

  • Microbiology
  • Immunology
  • Orthopedics

Background:

  • Staphylococci, particularly Staphylococcus aureus, are the leading cause of global bone infections.
  • Antibiotic resistance and increased prosthetic joint surgeries exacerbate these difficult-to-treat infections.
  • Understanding bacterial mechanisms is crucial for developing novel therapeutic strategies.

Purpose of the Study:

  • To review the mechanisms by which staphylococci infect and damage bone.
  • To discuss the role of the inflammatory response in bone destruction during infection.
  • To explore bacterial virulence factors and intracellular invasion in bone pathology.

Main Methods:

  • Literature review of current research on staphylococcal bone infections.
  • Analysis of the inflammatory response and its impact on bone homeostasis.
  • Discussion of bacterial virulence factors and intracellular persistence.

Main Results:

  • Staphylococcal infections disrupt bone matrix balance, leading to destruction.
  • Virulence factors contribute to bone infection, but none are exclusively specific.
  • Intracellular invasion by staphylococci may facilitate persistent infections and immune evasion.

Conclusions:

  • Staphylococcal bone infections involve complex interactions between bacteria, host immunity, and bone metabolism.
  • 'Small colony variant' strains pose significant challenges due to intracellular persistence and antimicrobial resistance.
  • Further research into bacterial virulence and host-pathogen interactions is needed for effective treatment development.