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Updated: Jun 19, 2026
![[(DPEPhos)(bcp)Cu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59739.jpg&w=3840&q=50)
[(DPEPhos)(bcp)Cu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Decomposition pathways for the photoactivated anticancer complex cis,trans,cis-[Pt(N3)2(OH)2(NH3)2]: insights from
Luca Salassa1, Hazel I A Phillips, Peter J Sadler
1Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry, UK CV4 7AL.
Abstract:
Density functional theory (DFT) and time-dependent DFT (TD-DFT) provide new insights into the photodegradation pathways of the cytotoxic complex cis,trans,cis-[Pt(N(3))(2)(OH)(2)(NH(3))(2)] allowing assignment of (1)LMCT transitions in the visible region of the UV-Vis spectrum; upon excitation to these low-energy (1)LMCT states, release of one N(3)(-) ligand is facilitated, and on triplet formation, the dissociation of both NH(3) and N(3)(-) groups trans to each other is promoted with no apparent reduction of the Pt(IV) centre.
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