Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer02:18

Cancer

53.4K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
53.4K
Metastasis02:30

Metastasis

6.3K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
6.3K
Tumor Progression02:07

Tumor Progression

7.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.2K
Traumatic Memory01:20

Traumatic Memory

527
Emotionally traumatic events often lead to memories that are exceptionally vivid and enduring, sometimes persisting with remarkable clarity throughout an individual's life. A classic example of this phenomenon is a person who survives a car accident. Even years later, they may recall every detail of the event with startling accuracy — the screeching of the tires, the jarring impact, and the acrid smell of burning rubber. Such vividness contrasts sharply with how an individual...
527
Post-traumatic Stress Disorder01:27

Post-traumatic Stress Disorder

462
Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
462
The Tumor Microenvironment02:17

The Tumor Microenvironment

7.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An audit of the quality of care of traumatic brain injury at a busy regional hospital in South Africa.

South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie·2010
Same author

The spectrum of diaphragmatic injury in a busy metropolitan surgical service.

Injury·2009
Same author

The spectrum and outcome of burns at a regional hospital in South Africa.

Burns : journal of the International Society for Burn Injuries·2009
Same author

Retroperitoneal haematoma and related organ injury--management approach.

South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie·2003
Same author

Ventilation and the critically ill parturient.

Best practice & research. Clinical obstetrics & gynaecology·2001
Same author

Management of penetrating cervicomediastinal venous trauma.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2000
Same journal

SAMA Health Summit Abstracts.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
Same journal

On behalf of the South African Medical Association (SAMA), The Scientific Committee of the SAMA Health Summit, is pleased to pesent this abstract issue, showcasing the posters and oral presentations delivered at the Summit, which was held from 22-24 May 2026.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
Same journal

Proceedings of the 2<sup>nd</sup> Data Driven Surgery Conference (DDSC 2025).

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
Same journal

Clinical practice guidelines for the management of fever and neutropenia in South African children and adolescents with cancer.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
Same journal

The changing fortunes of the District Health System in SA (1994 - 2020): A retrospective review.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
Same journal

Thomas Micheal Guntram Ignaz Rehle (1951 - 2025).

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
See all related articles

Related Experiment Video

Updated: Jan 12, 2026

A Novel In Vitro Model of Blast Traumatic Brain Injury
08:59

A Novel In Vitro Model of Blast Traumatic Brain Injury

Published on: December 21, 2018

11.1K

Trauma--the malignant epidemic.

D J Muckart1

  • 1Department of Surgery, University of Natal, Durban.

South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
|January 19, 1991
PubMed
Summary
This summary is machine-generated.

Trauma is the leading cause of death for children and young adults in the US and UK, with injury deaths surpassing all other causes for those under 35. Urgent trauma care programs and stricter regulations are needed to address this growing epidemic.

More Related Videos

A Coupled Experiment-finite Element Modeling Methodology for Assessing High Strain Rate Mechanical Response of Soft Biomaterials
11:28

A Coupled Experiment-finite Element Modeling Methodology for Assessing High Strain Rate Mechanical Response of Soft Biomaterials

Published on: May 18, 2015

12.9K
Pseudofracture: An Acute Peripheral Tissue Trauma Model
10:08

Pseudofracture: An Acute Peripheral Tissue Trauma Model

Published on: April 18, 2011

15.2K

Related Experiment Videos

Last Updated: Jan 12, 2026

A Novel In Vitro Model of Blast Traumatic Brain Injury
08:59

A Novel In Vitro Model of Blast Traumatic Brain Injury

Published on: December 21, 2018

11.1K
A Coupled Experiment-finite Element Modeling Methodology for Assessing High Strain Rate Mechanical Response of Soft Biomaterials
11:28

A Coupled Experiment-finite Element Modeling Methodology for Assessing High Strain Rate Mechanical Response of Soft Biomaterials

Published on: May 18, 2015

12.9K
Pseudofracture: An Acute Peripheral Tissue Trauma Model
10:08

Pseudofracture: An Acute Peripheral Tissue Trauma Model

Published on: April 18, 2011

15.2K

Area of Science:

  • Public Health
  • Trauma Surgery
  • Epidemiology

Background:

  • Trauma is the primary cause of mortality in children and young adults in the USA and UK.
  • Injury-related deaths exceed those from malignant disease, heart disease, and AIDS combined in pre-retirement years in the Western world.
  • A similar escalating pattern of trauma incidence is observed in South Africa, despite ongoing infectious disease burdens.

Purpose of the Study:

  • To highlight the significant and increasing burden of trauma as a cause of death and disability in young populations.
  • To identify key contributing factors to trauma, including motor vehicle accidents and firearm-related injuries.
  • To advocate for improved trauma care systems and legislative control measures.

Main Methods:

  • This abstract presents a review of existing data and trends regarding trauma mortality and incidence.
  • It analyzes the correlation between societal factors such as alcohol consumption, vehicle speed, and firearm ownership with injury rates.
  • The text discusses the need for legislative and systemic interventions.

Main Results:

  • Trauma is the leading cause of death in young populations in the USA and UK.
  • Injury deaths outnumber deaths from all other causes combined in individuals under 35 years of age.
  • Alcohol, speed, and firearm availability are major contributors to accidental and non-accidental injuries.

Conclusions:

  • There is an urgent need for stricter legislation on alcohol, driving, and firearm control.
  • A regionalized trauma care program is essential to manage the escalating trauma epidemic.
  • Intervention strategies must address both the causes of injury and the provision of effective trauma care.