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Related Concept Videos

Renal Corpuscle01:20

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
Nephrons01:10

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma happens...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Blood and Nerve Supply to the Kidney01:18

Blood and Nerve Supply to the Kidney

The kidneys are vital organs responsible for filtering and cleaning blood, removing waste products, and regulating electrolyte levels. To perform these essential functions, they require a constant and robust blood supply.
Bloody Supply to the Kidneys:
The kidneys receive their blood supply from the renal arteries, which branch off from the abdominal aorta—the main artery supplying the abdomen and lower body. The renal arteries enter the kidneys at the hilum, a notch on the medial side of each...
Acute Pyelonephritis I: Introduction01:27

Acute Pyelonephritis I: Introduction

Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such as Proteus,...

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Related Experiment Video

Updated: Jun 19, 2026

Intravascular Delivery of Biologics to the Rat Kidney
07:29

Intravascular Delivery of Biologics to the Rat Kidney

Published on: September 1, 2016

Vasculitis affecting the kidney.

Rohan John1, Andrew M Herzenberg

  • 1Department of Pathology, University Health Network, University of Toronto, Toronto, ON, Canada.

Seminars in Diagnostic Pathology
|November 7, 2009
PubMed
Summary
This summary is machine-generated.

Kidney vasculitis, often small vessel vasculitis (SVV), involves leukocyte infiltration and necrosis. Anti-neutrophilic cytoplasmic antibodies (ANCA) are key in diagnosing and understanding the pathology of ANCA-associated vasculitis.

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Last Updated: Jun 19, 2026

Intravascular Delivery of Biologics to the Rat Kidney
07:29

Intravascular Delivery of Biologics to the Rat Kidney

Published on: September 1, 2016

Whole-Kidney Three-Dimensional Staining with CUBIC
04:31

Whole-Kidney Three-Dimensional Staining with CUBIC

Published on: July 18, 2022

Area of Science:

  • Nephrology
  • Immunology
  • Pathology

Background:

  • Vasculitis is vessel wall inflammation, commonly affecting the kidneys.
  • Classification is based on vessel size: large, medium, and small vessel disease.
  • Small vessel vasculitis (SVV) with glomerulonephritis is the most frequent renal vasculitic lesion.

Purpose of the Study:

  • To review clinical and pathological features of kidney vasculitides.
  • To emphasize SVV, especially ANCA-associated vasculitis.
  • To discuss the role of anti-neutrophilic cytoplasmic antibodies (ANCA) in pathogenesis.

Main Methods:

  • Literature review of clinical and pathological data.
  • Classification of vasculitis by vessel size.
  • Focus on histopathology and serological markers like ANCA.

Main Results:

  • Small vessel vasculitis presents as necrotizing crescentic glomerulonephritis.
  • Medium vessel vasculitis can cause necrotizing arteritis; large vessel vasculitis rarely affects kidneys directly.
  • ANCA are crucial for diagnosing and understanding SVV pathogenesis.

Conclusions:

  • Kidney involvement in vasculitis varies by vessel size and type.
  • Histopathology alone is often insufficient; clinical data are essential for classification.
  • ANCA play a significant pathogenic role in specific vasculitides affecting the kidney.