Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies. Common...
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

The pathophysiology of pneumonia involves the following steps:
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
Pneumonia I: Introduction01:29

Pneumonia I: Introduction

Pneumonia is an infection of the lower respiratory tract that leads to inflammation of the lung parenchyma, often resulting in the accumulation of inflammatory exudate in the alveoli and airways. Unlike the watery, low-protein fluid exudate in pulmonary edema, the exudate in this case is a thick fluid rich in immune cells, proteins, and debris produced during infection and inflammation.This impairs gas exchange and can lead to consolidation of lung tissue. The infection may be caused by a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quality improvement model (IHI) as a strategy to implement a sepsis protocol in a public hospital in Brazil.

BMJ open quality·2020
Same author

Assessment of the peripheral microcirculation in patients with and without shock: a pilot study on different methods.

Journal of clinical monitoring and computing·2019
Same author

Comparison of three transfusion protocols prior to central venous catheterization in patients with cirrhosis: A randomized controlled trial.

Journal of thrombosis and haemostasis : JTH·2019
Same author

Inducing Brain Cooling Without Core Temperature Reduction in Pigs Using a Novel Nasopharyngeal Method: An Effectiveness and Safety Study.

Neurocritical care·2019
Same author

Efficiency in the operational process: reduction of incorrect entries and guarantee of compliance in the rendering of accounts.

Einstein (Sao Paulo, Brazil)·2018
Same author

Thromboelastometry profile in critically ill patients: A single-center, retrospective, observational study.

PloS one·2018

Related Experiment Video

Updated: Jun 19, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
07:30

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

Evolving concepts in sepsis definitions.

Jean-Louis Vincent1, Eva Ocampos Martinez, Eliezer Silva

  • 1Department of Intensive Care, Erasme University Hospital, Université libre de Bruxelles, Brussels, Belgium. jlvincen@ulb.ac.be

Critical Care Clinics
|November 7, 2009
PubMed
Summary
This summary is machine-generated.

Standardizing sepsis definitions is crucial for research and treatment. However, clinical diagnosis remains challenging, necessitating evolving concepts for better patient outcomes.

More Related Videos

A Data-Driven Approach to Quantifying Immune States in Sepsis
07:42

A Data-Driven Approach to Quantifying Immune States in Sepsis

Published on: February 7, 2025

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats
05:56

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats

Published on: February 20, 2021

Related Experiment Videos

Last Updated: Jun 19, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
07:30

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

A Data-Driven Approach to Quantifying Immune States in Sepsis
07:42

A Data-Driven Approach to Quantifying Immune States in Sepsis

Published on: February 7, 2025

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats
05:56

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats

Published on: February 20, 2021

Area of Science:

  • Critical Care Medicine
  • Infectious Diseases
  • Clinical Practice

Background:

  • Standardized definitions for sepsis are vital for accurate diagnosis, treatment, clinical trial inclusion, and study comparisons.
  • Despite published consensus definitions, diagnosing sepsis in clinical practice remains difficult.
  • Many patients with sepsis do not receive timely, life-saving specific therapies.

Purpose of the Study:

  • To highlight the ongoing challenges in sepsis diagnosis and treatment despite standardized definitions.
  • To advocate for the evolution of sepsis concepts beyond global definitions.
  • To emphasize the need for improved individual diagnosis and disease characterization strategies.

Main Methods:

  • This study is a conceptual review and analysis of existing sepsis definitions and clinical practice challenges.
  • It synthesizes information from consensus conferences and clinical observations.
  • No new experimental data were generated; the focus is on critical appraisal of current approaches.

Main Results:

  • Current consensus definitions, while important, have not fully resolved the difficulties in clinical sepsis diagnosis.
  • The gap persists between standardized definitions and practical application, leading to delayed treatment.
  • Effective sepsis management requires more than just standardized nomenclature.

Conclusions:

  • Sepsis diagnostic and treatment strategies require evolution beyond current global definitions.
  • Integrating better individual diagnostic and disease characterization tools is essential.
  • Rapid, appropriate treatment based on enhanced individual assessment is key to improving patient survival rates.