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Enhanced insulin sensitivity in prepubertal children with constitutional delay of growth and development

Dyanne A Wilson1, Paul L Hofman, Harriet L Miles

  • 1Liggins Institute and National Research Centre for Growth and Development, University of Auckland, Private Bag 92019, Auckland, New Zealand.

The Journal of Pediatrics
|November 7, 2009
PubMed

Insights

Children with constitutional delay of growth and development (CDGD) show significantly enhanced insulin sensitivity. This finding supports the link between insulin sensitivity and the timing of puberty onset.

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Regulation
  • Growth and Development

Background:

  • Constitutional delay of growth and development (CDGD) is a common condition in children.
  • The relationship between insulin sensitivity and pubertal timing in CDGD is not fully understood.

Purpose of the Study:

  • To investigate insulin sensitivity in prepubertal children with presumed CDGD.
  • To test the hypothesis that enhanced insulin sensitivity is associated with later pubertal onset in these children.

Main Methods:

  • A frequently sampled intravenous glucose tolerance test was performed.
  • Evaluated insulin sensitivity, glucose regulation, and growth markers in 21 children with CDGD and 23 controls.

Main Results:

  • Children with CDGD exhibited 40% greater insulin sensitivity compared to controls.
  • The CDGD group had reduced acute insulin response and lower insulin-like growth factor binding protein 3 levels.
  • Lower serum insulin-like growth factor-II levels were observed in the CDGD group.

Conclusions:

  • Prepubertal children with CDGD possess enhanced insulin sensitivity.
  • This supports the hypothesis linking insulin sensitivity to pubertal timing.
  • Enhanced insulin sensitivity may confer long-term benefits, including reduced risk of metabolic syndrome and malignancy.
Abstract

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