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Updated: Jun 19, 2026
10:23
Covalent Binding of BMP-2 on Surfaces Using a Self-assembled Monolayer Approach
Published on: August 26, 2013
Bone morphogenetic proteins in orthopaedic surgery.
T William Axelrad1, Thomas A Einhorn
1Department of Orthopaedic Surgery, Boston University Medical Center, Boston, MA, United States.
Cytokine & Growth Factor Reviews
|November 7, 2009
Summary
Bone healing can be delayed, causing pain and increased medical costs. Bone morphogenetic proteins (BMPs) like BMP-2 and BMP-7 show promise in treating nonunion and failed fusions, but their use and complications require careful review.
Area of Science:
- Orthopedics
- Regenerative Medicine
- Biomaterials
Background:
- Bone healing is typically successful but can be inhibited in certain patients and clinical situations.
- Delayed bone healing leads to significant morbidity, including pain, prolonged treatment, and lost work time.
- Nonunion and failed spinal fusions represent major clinical challenges.
Purpose of the Study:
- To review the use of growth factors in bone healing.
- To discuss approved bone morphogenetic proteins (BMPs), specifically BMP-2 and BMP-7.
- To examine potential complications associated with BMP therapy.
Main Methods:
- Literature review of bone healing processes.
- Analysis of approved growth factor applications (BMP-2, BMP-7).
- Discussion of clinical outcomes and adverse events.
Main Results:
- Bone morphogenetic proteins (BMP-2 and BMP-7) are approved for specific indications.
- These growth factors can aid in bone regeneration and fusion.
- Potential complications and risks associated with their use exist and are reviewed.
Conclusions:
- Growth factors like BMP-2 and BMP-7 offer therapeutic potential for bone healing complications.
- Careful consideration of approved indications and potential adverse effects is crucial for effective BMP use.
- Further research may optimize BMP applications for enhanced bone repair.
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