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Related Experiment Video

Updated: Jul 16, 2026

Direct Mouse Trauma/Burn Model of Heterotopic Ossification

Direct Mouse Trauma/Burn Model of Heterotopic Ossification

Published on: August 6, 2015

Fibrodysplasia Ossificans Progressiva.

Kevin Alexander Kuenzler¹, Anita Schwendimann¹, Paul Schumann¹

¹Department of Oral and Maxillofacial Surgery, University Hospital Zurich, Switzerland. kevin.kuenzler@usz.ch.

Swiss Dental Journal

|July 15, 2026

Summary

Fibrodysplasia ossificans progressiva (FOP) management in a patient with complete jaw immobility required careful dental extraction under general anesthesia. This approach improved oral hygiene, reduced pain, and enhanced nutrition, demonstrating the importance of specialized care.

Keywords:

Fibrodysplasia Ossificans Progressiva Oral- and maxillofacial surgery Temporomandibular Joint Ankylosis Tooth Extraction

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Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects

Published on: April 11, 2012

Area of Science:

Dentistry
Genetics
Medical Case Reports

Background:

Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder causing progressive heterotopic ossification.
Orofacial involvement in FOP can lead to severe jaw immobility (temporomandibular ankylosis), complicating oral hygiene and dental treatment.
A 25-year-old male with advanced FOP presented with 0 mm interincisal opening, daily dental pain, and poor oral hygiene.

Purpose of the Study:

To describe the management of dental issues in a patient with advanced FOP and complete jaw immobility.
To highlight the challenges and successful strategies for dental intervention in FOP patients.
To emphasize the importance of interdisciplinary planning and trauma avoidance in FOP dental care.

Main Methods:

Computed tomography (CT) was used for dental assessment due to the inability to perform conventional radiography.
Interdisciplinary planning involving anesthesiology and FOP specialists was crucial.
Surgical extraction of posterior teeth was performed under general anesthesia with awake fiberoptic nasotracheal intubation and standby tracheostomy, avoiding local anesthetic injections and minimizing trauma.

Main Results:

The dental extraction procedure was completed without complications.
At 11-month follow-up, the patient was free of dental pain and swelling, with improved food intake and weight gain.
The intervention successfully improved oral cleanability and reduced the risk of inflammatory complications.

Conclusions:

This case underscores the necessity of preventive dentistry and strict indications for invasive procedures in FOP patients.
Multidisciplinary planning, airway preparedness, and meticulous trauma avoidance are essential for successful dental management.
Long-term dental follow-up in specialized centers is critical for managing FOP-related orofacial complications.